iChem Filter Inserts


We are pleased to offer the first-kind of In-Vial Filter Insert, an iChem consumable from Reaction Analytics. This new filter insert has been designed and developed in collaboration with the pharmaceutical Enabling Technologies Consortium (ETC) members. The insert brings real time sample filtration to the standard 1 mL or 2 mL vial, freeing you from tedious syringe filtration or centrifugation for solid-liquid phase separation. Just drop in the insert into the vial at any time, the spontaneously filtered solution is ready for sampling. 


  • The PTFE filter insert material provides a broad chemical compatibility in a temperature operating range of 5 – 100 C
  • The PTFE porous filter membrane treated to be moderately hydrophilic
  • By dynamic diffusion across the filter membrane, the filtrate inside of the insert is in equilibrium with the vial solution for real time sampling

Package :

  • 50 filter inserts per bag. Please Contact us for price and order.

Use with :

  • 2 mL vial (12 X 32 mm) with 1 mL solution
  • 1 mL tube (7 X 30 mm) with 250 µL solution
  • Recommend use of a stir bar (e.g. 2×5 mm) to enhance diffusion. Check that stir bar is clear of the filter as it can strike to damage the filter.
  • Insert clearance: 5 mm for 2 mL vial and 4 mm for 1 mL vial from filter end to vial bottom. Adjust the autosampler’s sampling needle height to prevent from piercing the filter membrane.

Functional Tests:

  • Solvent permeation: Observe filtrate volume instantly 
  • Solvent compatibility: Stir and heat in various solvents
  • Seal integrity: In-vial filter 2-12 µm particle size charcoal
  • Solvents tested: DMSO, Methanol, Acetonitrile, THF, Acetone, Ethyl Acetate, Toluene, Heptane, IPA/Water (50/50), and Acetonitrile/Water (10/90)


  • To filter a saturated solution from solubility and crystallization studies
  • To filter a solution with heterogeneous catalyst from reaction screening
  • To filter a solution with a solid matrix for soluble analyte, e.g. stress study or extraction of active pharmaceutical ingredient from drug product at the presence of insoluble excipients

Example Study of Solubility vs. Temperature:

Example Study of Aqueous Solubility at 37C: